Protein Modification Reagents
Ubpbio TCEP Powder, 25 GR, CAS# 51805-45-9
Reducing Agents - TCEP - TCEP (tris(2-carboxyethyl)phosphine) is a strong reducing agent. Compared to dithiothreitol (DTT) and β-mercaptoethanol, TCEP has the advantages of being odorless, a more powerful reducing agent, an irreversible reducing agent, more hydrophilic, and more resistant to oxidation in air. It is soluble in water and stable at neutral pH. It does not reduce metals used in immobilized metal affinity chromatography such as Ni-NTA resin. TCEP is particularly useful when labeling cysteine residues with maleimides.
Cayman Chemical DL-DIthIothreItol 1g
A reducing agent; has been used to stabilize thiols in a reduced state in various applications, including protein purification and enzymatic assays
Hampton Research HR2-428-43/Additive Screen 43 (D07), 1.0 ml - 1.0 M Guanidine hydrochloride
HR2-428-43/Additive Screen 43 (D07), 1.0 ml - 1.0 M Guanidine hydrochloride. Please note items from this supplier are non-returnable.
![Medchemexpress LLC L-Prolinamide, N-[2-[3-[4-[3-[4-[[5-bromo-4-[[3-[(cyclobutylcarbonyl)methylamino]propyl]amino]-... | 2052306-13-3 | 98.2% | 1093.18 g/mol | C53H74BrN9O9S | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000264323.png-250.jpg)
Medchemexpress LLC L-Prolinamide, N-[2-[3-[4-[3-[4-[[5-bromo-4-[[3-[(cyclobutylcarbonyl)methylamino]propyl]amino]-... | 2052306-13-3 | 98.2% | 1093.18 g/mol | C53H74BrN9O9S | 5 MG
PROTAC TBK1 degrader-2 is a small-molecule PROTAC that binds and induces degradation of TANK-binding kinase 1 (TBK1). It shows potent biochemical and cellular activity and is intended for target validation and mechanism-of-action studies in research settings.
- Potent degradation of TBK1 (DC50 = 15 nM).
- High binding affinity to TBK1 (Kd = 4.6 nM).
- Low-nanomolar inhibitory activity (IC50 TBK1 = 1.3 nM; IKKε = 8.7 nM).
- High reported purity suitable for research (98.2%).
- White to off-white solid with good DMSO solubility (110 mg/mL).
- Intended for cellular and biochemical PROTAC studies and target validation.
eMolecules Bis-PEG4-NHS ester | Broadpharm | 1314378-11-4 | MFCD20228963 | 488.446 | C20H28N2O12 | 98.000 | O=C(CCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O)ON1C(=O)CCC1=O | 1g | 208572581
Bis-PEG4-NHS ester | Broadpharm | 1314378-11-4 | MFCD20228963 | 488.446 | C20H28N2O12 | 98.000 | O=C(CCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O)ON1C(=O)CCC1=O | 1g | 208572581
eMolecules Acid-PEG5-NHS ester | 1343476-41-4 | 500MG | Purity: 95%
Broadpharm | Acid-PEG5-NHS ester | 500MG | 1343476-41-4 | MFCD15204346 | MW:418.41
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Medchemexpress LLC Aminooxy-PEG5-azide | 1919045-02-5 | 98.3% | 100 MG
Aminooxy-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. This click chemistry reagent contains an azide group, allowing it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing alkyne groups. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Functions as a PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Acts as a click chemistry reagent
- Features an azide group for CuAAc reactions
- Capable of SPAAC reactions with DBCO or BCN groups
Medchemexpress LLC Bis-PEG4-PFP ester | 1314378-12-5 | 97.0% | 250 MG
Bis-PEG4-PFP ester is a PROTAC linker that is PEG-based and can be utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets a specific protein. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Consists of two distinct ligands connected by a linker
- Targets an E3 ubiquitin ligase with one ligand
- Targets a specific protein with the other ligand
- Leverages the intracellular ubiquitin-proteasome system
- Enables selective degradation of target proteins
Medchemexpress LLC Biotin-PEG4-amide-alkyne | 1006592-45-5 | MFCD16621136 | 95.0% | C24H40N4O7S | 10MG
Biotin-PEG4-amide-alkyne is a polyethylene glycol (PEG)-based linker reagent that combines a biotin affinity tag with a terminal alkyne group for click chemistry applications. Supplied as an off-white to light yellow solid (CAS 1006592-45-5), it is designed for bioconjugation, affinity capture, and incorporation into PROTAC and probe chemistries.
- Contains a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Includes a biotin moiety for strong affinity capture and detection.
- Features a PEG4 spacer to enhance aqueous solubility and reduce steric hindrance.
- Supplied as a stable solid suitable for storage and handling in research labs.
- Applicable to bioconjugation, probe synthesis, and PROTAC linker construction.
Medchemexpress LLC Peg4-aminooxy-MMAF | 1415246-35-3 | 923.19 | C47H82N6O12 | 50 MG
PEG4-aminooxy-MMAF is a drug-linker conjugate intended for antibody-drug conjugate (ADC) research. It links the antitubulin payload MMAF to a noncleavable PEG4 spacer terminated with an aminooxy functional group, enabling oxime-based conjugation to aldehyde- or ketone-containing antibodies or linkers.
- Drug-linker conjugate for ADC research.
- Contains an aminooxy-terminated PEG4 spacer for oxime conjugation.
- MMAF payload provides potent antitubulin activity.
- Molecular weight 923.19.
- Chemical formula C47H82N6O12.
- Available in small research pack sizes, including 50 mg.
eMolecules t-Boc-N-amido-PEG4-NHS ester | Broadpharm | 859230-20-9 | MFCD20228887 | 462.496 | C20H34N2O10 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 1g | 340377001
t-Boc-N-amido-PEG4-NHS ester | Broadpharm | 859230-20-9 | MFCD20228887 | 462.496 | C20H34N2O10 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 1g | 340377001
![eMolecules Broadpharm / Mal-PEG1-PNP-carbonate / 100mg / 573896599 / BP-24465 / 98.000 / 1345681-74-4 / [null] / 350.283 / C15H14N2O8](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502480679.JPG-250.jpg)
eMolecules Broadpharm / Mal-PEG1-PNP-carbonate / 100mg / 573896599 / BP-24465 / 98.000 / 1345681-74-4 / [null] / 350.283 / C15H14N2O8
Broadpharm / Mal-PEG1-PNP-carbonate / 100mg / 573896599 / BP-24465 / 98.000 / 1345681-74-4 / [null] / 350.283 / C15H14N2O8